6th July 2020: 'Dynamic integration of metabolism and growth factor signaling in single cells' - John Albeck, UC Davis, Davis, USA
Duration: 1 hour 8 mins
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| Description: |
Abstract:
Cell growth and proliferation are regulated by a network of kinases, including ERK, Akt, mTOR, and AMPK. These kinases have important complementary roles in maintaining tissue homeostasis and are frequently deregulated in cancers. While ERK, Akt, and mTOR stimulate the anabolic processes of cell cycle progression and protein translation, AMPK induces catabolic activity to balance the cellular energy budget. Using live-cell reporters for these kinases, we have uncovered an intricate interplay of activation kinetics that cannot be detected at the population level. These patterns integrate extracellular growth factor and nutrient signals within the cell, and influence the gene expression and behavior of individual cells. By taking into account single-cell data, we are working toward therapeutic strategies that optimize both individual and population-level cellular responses to maximize the intended effects on cell behavior. https://www.mcb.ucdavis.edu/faculty-labs/albeck/index.htm |
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| Created: | 2020-07-06 16:57 |
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| Collection: | Imaging ONE WORLD |
| Publisher: | University of Cambridge |
| Copyright: | John Albeck |
| Language: | eng (English) |
| Distribution: |
World
(not downloadable)
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| Keywords: | Microscopy; cell cycle; single cells; |
| Explicit content: | No |
| Aspect Ratio: | 16:9 |
| Screencast: | No |
| Bumper: | UCS Default |
| Trailer: | UCS Default |
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